Polymorphic G-Protein-Coupled Receptors and Associated Diseases

Polymorphisms are quite common in the human population. Most likely every gene could be polymorphic. Most of these variations are common and have no functional consequence. However, as we learn more about the function of G-protein-coupled receptors (GPCRs) and how amino acid differences can modulate the function enough to measure, especially in a compromised physical state, the importance of characterizing these variations becomes substantial....