Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth

Volume: 140, Issue: 10, Pages: 2130 - 2138
Published: May 15, 2013
Abstract
Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior-posterior and proximal-distal specification initiates in early limb bud concomitantly with the proliferative expansion of limb cells. Previous studies have shown that limb bud growth initially relies on fibroblast growth factors (FGFs) produced in the apical ectodermal ridge (AER-FGFs), the maintenance of...
Paper Details
Title
Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth
Published Date
May 15, 2013
Volume
140
Issue
10
Pages
2130 - 2138
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