Recombinant Variant of Ciliary Neurotrophic Factor for Weight Loss in Obese Adults

Obese individuals tend to resist the weight-regulating effects of exogenously administered leptin. A genetically engineered recombinant human variant ciliary neurotrophic factor (rhvCNTF) that signals through leptinlike pathways in the hypothalamus has been shown to bypass leptin resistance in animal models of obesity.To identify a safe and well-tolerated dose of rhvCNTF that causes weight loss in obese adults.Twelve-week, double-blind,...