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Clinical Characteristics and Risk Factors of Diabetic Foot Ulcer With Multidrug- Resistant Organism Infection
Published on Mar 1, 2014in The International Journal of Lower Extremity Wounds 1.21
· DOI :10.1177/1534734614521236
Xiaoyan Ji3
Estimated H-index: 3
(Tianjin Medical University),
Peng Jin1
Estimated H-index: 1
(Tianjin Medical University)
+ 2 AuthorsPenghua Wang4
Estimated H-index: 4
(Tianjin Medical University)
Abstract
The objective was to determine multidrug-resistant organisms’ (MDROs) profile in diabetic foot ulcers (DFU), antibiotic resistance of MDROs, and to find the potential risk factors for infection with MDROs. In 157 patients with DFU admitted to Tianjin Metabolic Disease Hospital, China, from January 2011 to January 2012, microbiological specimens were taken on admission. The patients were divided into 2 groups according to the infection of MDROs. Potential risk factors for MDRO-positive specimens were examined using univariate and multivariate analyses. Seventy-eight MDRO strains were isolated from patients in the MDRO+ group, among which the top 3 were Staphylococcus aureus (16.7%), Enterobacter spp (16.7%), and Pseudomonas aeruginosa (15.4%). Most of the MDROs were resistant to at least 8 kinds of commonly used antibiotics. Gram-negative MDROs showed 23% to 50% resistance to third-generation cephalosporins. The resistant rates of Gram-positive MDROs to fluoroquinolone were more than 70%; penicillin and se...
  • References (47)
  • Cited By (4)
Cite
References47
Published on Jan 1, 1996in Diabetic Medicine 3.13
J.W.M. van der Meer1
Estimated H-index: 1
,
P.P. Koopmans19
Estimated H-index: 19
,
Jos A. Lutterman18
Estimated H-index: 18
18 Citations Source Cite
Published on Feb 1, 2011in Diabetic Medicine 3.13
Javier Aragón-Sánchez16
Estimated H-index: 16
,
Benjamin A. Lipsky68
Estimated H-index: 68
(University of Washington),
José Luis Lázaro-Martínez14
Estimated H-index: 14
(Complutense University of Madrid)
Diabet. Med. 28, 191–194 (2011) Abstract Aims To investigate the accuracy of the sequential combination of the probe-to-bone test and plain X-rays for diagnosing osteomyelitis in the foot of patients with diabetes. Methods We prospectively compiled data on a series of 338 patients with diabetes with 356 episodes of foot infection who were hospitalized in the Diabetic Foot Unit of La Paloma Hospital from 1 October 2002 to 31 April 2010. For each patient we did a probe-to-bone test at the time of ...
79 Citations Source Cite
Published on Feb 1, 2012in Diabetes-metabolism Research and Reviews 3.90
Benjamin A. Lipsky68
Estimated H-index: 68
(University of Washington),
Edgar J.G. Peters26
Estimated H-index: 26
(VU University Amsterdam)
+ 5 AuthorsWilliam Jeffcoate43
Estimated H-index: 43
(University of Nottingham)
Summary This update of the International Working Group on the Diabetic Foot incorporates some information from a related review of diabetic foot osteomyelitis (DFO) and a systematic review of the management of infection of the diabetic foot. The pathophysiology of these infections is now well understood, and there is a validated system for classifying the severity of infections based on their clinical findings. Diagnosing osteomyelitis remains difficult, but several recent publications have clar...
122 Citations Source Cite
Markus W. Löffler8
Estimated H-index: 8
(University of Tübingen),
Heiko Schuster12
Estimated H-index: 12
(University of Tübingen)
+ 1 AuthorsStefan Beckert16
Estimated H-index: 16
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Published on Jan 1, 2013in Experimental and Therapeutic Medicine 1.41
Shanshan Zhang2
Estimated H-index: 2
(Shanghai Jiao Tong University),
Zheng-Yi Tang1
Estimated H-index: 1
(Shanghai Jiao Tong University)
+ 3 AuthorsGuang Ning1
Estimated H-index: 1
(Shanghai Jiao Tong University)
The prognosis for diabetic foot ulcers (DFUs) remains poor. Nutritional status has not been identified as one of the factors affecting the outcome of DFUs. Therefore, indicators correlated with nutritional status and outcome were analyzed to investigate their relationship. A total of 192 hospitalized patients with Wagner grade 1–5 ulcers and 60 patients with Wagner grade 0 ulcers (all had type 2 diabetes) were assessed by the following: subjective global assessment (SGA), anthropometric measurem...
17 Citations Source Cite
Published on Sep 1, 1999in Diabetic Medicine 3.13
N. Tentolouris1
Estimated H-index: 1
,
Edward B. Jude36
Estimated H-index: 36
+ 2 AuthorsA. J. M. Boulton36
Estimated H-index: 36
Summary Aim To study the prevalence of pathogenic organisms and the prevalence and outcome of methicillin-resistant Staphylococcus aureus (MRSA) infection in foot ulcers in diabetic patients. Methods A retrospective analysis of wound swabs taken from infected foot ulcers in diabetic patients, selected from an outpatient diabetic foot clinic. Seventy-five patients (79 ulcers) with positive wound swabs were included. Size of ulcer and time to healing, in particular for MRSA-infected ulcers, were m...
178 Citations Source Cite
Published on Apr 1, 2014in Diabetes, Obesity and Metabolism 5.98
Ilker Uckay28
Estimated H-index: 28
(Geneva College),
Karim Gariani14
Estimated H-index: 14
(Geneva College)
+ 1 AuthorsBenjamin A. Lipsky68
Estimated H-index: 68
(Geneva College)
Foot infections are frequent and potentially devastating complications of diabetes. Unchecked, infection can progress contiguously to involve the deeper soft tissues and ultimately the bone. Foot ulcers in people with diabetes are most often the consequence of one or more of the following: peripheral sensory neuropathy, motor neuropathy and gait disorders, peripheral arterial insufficiency or immunological impairments. Infection develops in over half of foot ulcers and is the factor that most of...
44 Citations Source Cite
Published on Oct 1, 2008in Diabetologia 6.02
L. Prompers5
Estimated H-index: 5
,
M. Huijberts22
Estimated H-index: 22
+ 16 AuthorsDidac Mauricio34
Estimated H-index: 34
(Hospital Universitari Arnau de Vilanova)
Aims/hypothesis The aim of the present study was to investigate resource utilisation and associated costs in patients with diabetic foot ulcers and to analyse differences in resource utilisation between individuals with or without peripheral arterial disease (PAD) and/or infection.
140 Citations Source Cite
Published on May 1, 2007in Journal of Infection 4.60
Özlem Kandemir7
Estimated H-index: 7
(Mersin University),
Esen Akbay11
Estimated H-index: 11
(Mersin University)
+ 2 AuthorsRamazan Gen8
Estimated H-index: 8
(Mersin University)
Summary Aim To investigate the risk factors for infection of the diabetic foot with multidrug resistant microorganisms. Methods Amongst 102 diabetic patients with evidence of soft tissue infection of the foot who presented to our health center over a three year period, we investigated risk factors that might be predictive of multi-antibiotic resistance of the infecting organism. Results Of 102 patients with a diabetic foot wound, bacteria were cultured from 73, yielding a total of 104 isolates. ...
56 Citations Source Cite
Marios Michail2
Estimated H-index: 2
(Athens State University),
Edward B. Jude36
Estimated H-index: 36
(University of Manchester)
+ 5 AuthorsNicholas Tentolouris19
Estimated H-index: 19
(Athens State University)
Serum inflammatory markers, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and procalcitonin (PCT), have been used for the diagnosis of foot infections in patients with diabetes. However, little is known about their changes during treatment of patients with foot infections. The aim of this prospective study was to examine the performance of serum inflammatory markers for the diagnosis and follow-up of patients with osteomyelitis. A total of 61 patients (...
41 Citations Source Cite
Cited By4
Jinghang Zhang2
Estimated H-index: 2
(Tianjin Medical University),
Yuejie Chu3
Estimated H-index: 3
(Tianjin Medical University)
+ 4 AuthorsYue Peng1
Estimated H-index: 1
(Tianjin Medical University)
4 Citations Source Cite
Published on Feb 1, 2018in International Journal of Infectious Diseases 3.20
Nese Saltoglu13
Estimated H-index: 13
(Istanbul University),
Onder Ergonul29
Estimated H-index: 29
(Koç University)
+ 34 AuthorsHaluk Eraksoy15
Estimated H-index: 15
(Istanbul University)
Abstract Objectives We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results In total, 791 patients with DFI ...
2 Citations Source Cite
Published on Aug 5, 2018in Experimental Diabetes Research
Mingxia Wu1
Estimated H-index: 1
(Third Military Medical University),
Hang Pan (Third Military Medical University)+ 3 AuthorsZiwen Liang5
Estimated H-index: 5
(Third Military Medical University)
Objective. To investigate the microbial distribution and drug susceptibility among diabetic foot ulcers (DFUs) with different Wagner grades and between acute and chronic DFUs. Methods. We enrolled 428 DFU patients who were hospitalized and treated in the Southwest Hospital. We collected deep ulcer secretion for microbial culture and drug susceptibility tests and analyzed the results. We reexamined 67 patients with poor anti-infection efficacy and analyzed microbial species. Results: The 354 posi...
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