Rapid fluid infusion therapy decreases the plasma concentration of continuously infused propofol

Rapid fluid infusion therapy to treat hypovolemia in anesthetized patients is a common practical regimen in daily clinical settings. This study investigated the effect of large volume loading on the plasma concentration of propofol (Cp), hemodynamic parameters, hemoglobin concentration (Hb), hematocrit value (Ht) and the bispectral index (BIS).Sixty patients were administered propofol using a target-controlled infusion technique. We studied two...