Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
Abstract
Isocitrate dehydrogenase (IDH) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and chondrosarcoma (CS). For AML, low-grade glioma and CC, mutant IDH status is associated with a DNA hypermethylation phenotype, implicating altered epigenome dynamics in the aetiology of these cancers. Here we show that the IDH variants in CS are also associated with a hypermethylation phenotype and...
Paper Details
Title
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
Published Date
Jul 18, 2013
Journal
Volume
4
Issue
1
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