Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells
Abstract
The major structural elements of retroviruses are contained in a single polyprotein, Gag, which in human immunodeficiency virus type 1 (HIV-1) comprises the MA, CA, spacer peptide 1 (SP1), NC, SP2, and p6 polypeptides. In the immature HIV-1 virion, the domains of Gag are arranged radially with the N-terminal MA domain at the membrane and C-terminal NC-SP2-p6 region nearest to the center. Here, we report the three-dimensional structures of...
Paper Details
Title
Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells
Published Date
Mar 29, 2007
Journal
Volume
26
Issue
8
Pages
2218 - 2226
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