Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
Abstract
Summary null Consumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circulating free FAs are known to be associated with T2D. Though previous studies showed inflammation is crucially involved in the development of insulin resistance, how inflammation contributes to β cell dysfunction has remained unclear. We report here the saturated FA palmitate induces β cell dysfunction in vivo by activating inflammatory...
Paper Details
Title
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
Published Date
Apr 4, 2012
Journal
Volume
15
Issue
4
Pages
518 - 533
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