Differential expression analysis for sequence count data.

Volume: 11, Issue: 10, Pages: 1 - 12
Published: Oct 27, 2010
Abstract
High-throughput sequencing assays such as RNA-Seq, ChIP-Seq or barcode counting provide quantitative readouts in the form of count data. To infer differential signal in such data correctly and with good statistical power, estimation of data variability throughout the dynamic range and a suitable error model are required. We propose a method based on the negative binomial distribution, with variance and mean linked by local regression and present...
Paper Details
Title
Differential expression analysis for sequence count data.
Published Date
Oct 27, 2010
Volume
11
Issue
10
Pages
1 - 12
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