Epithelial Tight Junctions in Intestinal Inflammation

Volume: 1165, Issue: 1, Pages: 294 - 300
Published: May 1, 2009
Abstract
The epithelium in inflamed intestinal segments of patients with Crohn's disease is characterized by a reduction of tight junction strands, strand breaks, and alterations of tight junction protein content and composition. In ulcerative colitis, epithelial leaks appear early due to micro-erosions resulting from upregulated epithelial apoptosis and in addition to a prominent increase of claudin-2. Th1-cytokine effects by interferon-gamma in...
Paper Details
Title
Epithelial Tight Junctions in Intestinal Inflammation
Published Date
May 1, 2009
Volume
1165
Issue
1
Pages
294 - 300
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