Avian metapneumovirus SH gene end and G protein mutations influence the level of protection of live-vaccine candidates.
Abstract
A prototype avian metapneumovirus (AMPV) vaccine (P20) was previously shown to give variable outcomes in experimental trials. Following plaque purification, three of 12 viruses obtained from P20 failed to induce protection against virulent challenge, whilst the remainder retained their protective capacity. The genome sequences of two protective viruses were identical to the P20 consensus, whereas two non-protective viruses differed only in the...
Paper Details
Title
Avian metapneumovirus SH gene end and G protein mutations influence the level of protection of live-vaccine candidates.
Published Date
Jun 1, 2007
Journal
Volume
88
Issue
6
Pages
1767 - 1775
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Notes
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