Inactivation-Deficient Human Skeletal Muscle Na+Channels (hNav1.4-L443C/A444W) in Stably Transfected HEK-293 Cells
Abstract
After transient transfection of an hNav1.4-L443C/A444W mutant clone, HEK-293 cells exhibited large inactivation-deficient Na+currents. We subsequently established a stable cell line expressing robust inactivation-deficient Na+currents. Persistent late Na+currents were far more sensitive to block by class 1 anti-arrhythmic flecainide, mexiletine, propafenone, and amiodarone at 10 microM than peak Na+currents. Such results support a hypothesis...
Paper Details
Title
Inactivation-Deficient Human Skeletal Muscle Na+Channels (hNav1.4-L443C/A444W) in Stably Transfected HEK-293 Cells
Published Date
Jan 1, 2004
Journal
Volume
10
Issue
3-4
Pages
131 - 138
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