Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association

Volume: 42, Issue: 10, Pages: 6393 - 6404
Published: Apr 20, 2014
Abstract
The Saccharomyces cerevisiae Rad1-Rad10 complex is a conserved, structure-specific endonuclease important for repairing multiple types of DNA lesions. Upon recruitment to lesion sites, Rad1-Rad10 removes damaged sequences, enabling subsequent gap filling and ligation. Acting at mid-steps of repair, the association and dissociation of Rad1-Rad10 with DNA can influence repair efficiency. We show that genotoxin-enhanced Rad1 sumoylation occurs...
Paper Details
Title
Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
Published Date
Apr 20, 2014
Volume
42
Issue
10
Pages
6393 - 6404
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