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Puberty and testosterone shape the corticospinal tract during male adolescence

Published on Mar 1, 2016in Brain Structure & Function3.62
· DOI :10.1007/s00429-014-0956-9
Melissa M. Pangelinan8
Estimated H-index: 8
,
LeonardGabriel34
Estimated H-index: 34
(McGill University)
+ 5 AuthorsTomáš Paus82
Estimated H-index: 82
(U of T: University of Toronto)
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Abstract
Some of the known sex differences in white matter emerge during adolescence. Here, we replicate and extend our previous findings of sex differences in the structure of the corticospinal tract (Perrin et al. 2009; Herve et al. 2009). In a large normative sample of adolescents, we observed age × sex interactions in the signal intensity of T1-weighted (T1W) images (n = 941) and in magnetization transfer ratio (MTR; n = 761); both features were inversely associated with age in males but not in females. Moreover, we hypothesized that the age-related differences in CST structure exhibited by males would be mediated by differences in puberty stage and levels of bioavailable testosterone. We confirmed this prediction using mediation analysis with bootstrapping. These findings suggest that sex differences in the CST structure observed during male adolescence may be due to multiple processes associated with puberty, including (but not limited to) the rising levels of testosterone.
  • References (68)
  • Citations (13)
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References68
Newest
Published on Sep 1, 2014in Neuroscience3.24
Tomáš Paus82
Estimated H-index: 82
(U of T: University of Toronto),
M. Pesaresi2
Estimated H-index: 2
(U of T: University of Toronto),
Leon French14
Estimated H-index: 14
(U of T: University of Toronto)
Abstract There are two ways to picture white matter: as a grid of electrical wires or a network of roads. The first metaphor captures the classical function of an axon as conductor of action potentials (and information) from one brain region to another. The second one points to the important role of axons in a bi-directional transport of biological molecules and organelles between the cell body and synapse. Given the wide variety of such cargoes, a well-functioning axonal transport is critical f...
Published on May 1, 2014in NeuroImage5.81
Daniel Simmonds5
Estimated H-index: 5
,
Michael N. Hallquist22
Estimated H-index: 22
(University of Pittsburgh)
+ 1 AuthorsBeatriz Luna44
Estimated H-index: 44
White matter (WM) continues to mature through adolescence in parallel with gains in cognitive ability. To date, developmental changes in human WM microstructure have been inferred using analyses of cross-sectional or two time-point follow-up studies, limiting our understanding of individual developmental trajectories. The aims of the present longitudinal study were to characterize the timing of WM growth and investigate how sex and behavior are associated with different developmental trajectorie...
Published on Mar 1, 2013in The Journal of Clinical Endocrinology and Metabolism5.61
Marinka M.G. Koenis7
Estimated H-index: 7
(UU: Utrecht University),
Rachel M. Brouwer31
Estimated H-index: 31
(UU: Utrecht University)
+ 6 AuthorsHilleke E. Hulshoff Pol68
Estimated H-index: 68
(UU: Utrecht University)
Context and Objective: Information on the correlation of normative reproductive hormone levels with physical development (Tanner stages) during puberty and on the influences of genes and environment on variation in these hormones and Tanner stages is limited. Design, Setting, and Participants: One hundred twelve healthy 9-year-old twin pairs (n = 224) took part in a longitudinal study, of which 89 pairs participated again at age 12 years (n = 178). Main Outcome Measures: Morning urinary LH, FSH,...
Ammar Khairullah2
Estimated H-index: 2
(U of T: University of Toronto),
Margaret T May47
Estimated H-index: 47
(UoB: University of Bristol)
+ 7 AuthorsTomáš Paus82
Estimated H-index: 82
(U of T: University of Toronto)
It is important to account for timing of puberty when studying the adolescent brain and cognition. The use of classical methods for assessing pubertal status may not be feasible in some studies, especially in male adolescents. Using data from a sample of 478 males from a longitudinal birth cohort, we describe the calculations of three independent height-based markers of pubertal timing: Age at Peak Height Velocity (APHV), Height Difference in Standard Deviations (HDSDS), and Percent Achieved of ...
Published on Sep 1, 2012in Cerebral Cortex5.44
Megan M. Herting19
Estimated H-index: 19
(OHSU: Oregon Health & Science University),
Emily C. Maxwell2
Estimated H-index: 2
(OHSU: Oregon Health & Science University)
+ 1 AuthorsBonnie J. Nagel33
Estimated H-index: 33
(OHSU: Oregon Health & Science University)
Background: During adolescence, numerous factors influence the organization of the brain. It is unclear what influence sex and puberty have on white matter microstructure, as well as the role that rapidly increasing sex steroids play. Methods: White matter microstructure was examined in 77 adolescents (ages 10–16) using diffusion tensor imaging. Multiple regression analyses were performed to examine the relationships between fractional anisotropy (FA) and mean diffusivity (MD) and sex, puberty, ...
Published on Aug 1, 2012in Psychoneuroendocrinology4.01
Giuseppina Rametti11
Estimated H-index: 11
,
Beatriz Carrillo9
Estimated H-index: 9
(UNED: National University of Distance Education)
+ 6 AuthorsAntonio Guillamón33
Estimated H-index: 33
(UNED: National University of Distance Education)
Summary Diffusion tensor imaging (DTI) can sensitively detect white matter sex differences and the effects of pharmacological treatments. Before cross-sex hormone treatment, the white matter microstructure of several brain bundles in female-to-male transsexuals (FtMs) differs from those in females but not from that in males. The purpose of this study was to investigate whether cross-sex hormone treatment (androgenization) affects the brain white matter microstructure. Using a Siemens 3 T Trio Ti...
Published on Jan 1, 2012in Developmental Cognitive Neuroscience4.92
Cecile D. Ladouceur29
Estimated H-index: 29
(University of Pittsburgh),
Jiska S. Peper29
Estimated H-index: 29
(LEI: Leiden University)
+ 1 AuthorsRonald E. Dahl99
Estimated H-index: 99
(University of California, Berkeley)
There have been rapid advances in understanding a broad range of changes in brain structure and function during adolescence, and a growing interest in identifying which of these neurodevelopmental changes are directly linked with pubertal maturation—at least in part because of their potential to provide insights into the numerous emotional and behavioral health problems that emerge during this developmental period. This review focuses on what is known about the influence of puberty on white matt...
Published on Jan 1, 2012in Brain11.81
Emma A. Webb6
Estimated H-index: 6
(ICH: UCL Institute of Child Health),
Michelle A O'reilly4
Estimated H-index: 4
(ICH: UCL Institute of Child Health)
+ 6 AuthorsMehul T. Dattani51
Estimated H-index: 51
(ICH: UCL Institute of Child Health)
The growth hormone-insulin-like growth factor-1 axis plays a role in normal brain growth but little is known of the effect of growth hormone deficiency on brain structure. Children with isolated growth hormone deficiency (peak growth hormone 10 µg/l) underwent cognitive assessment, diffusion tensor imaging and volumetric magnetic resonance imaging prior to commencing growth hormone treatment. Total brain, corpus callosal, hippocampal, thalamic and basal ganglia volumes were determined using Free...
Published on Sep 1, 2011in Brain Structure & Function3.62
Pierre-Yves Hervé12
Estimated H-index: 12
(University of Nottingham),
Eleanor F. Cox19
Estimated H-index: 19
(University of Nottingham)
+ 4 AuthorsTomáš Paus82
Estimated H-index: 82
(University of Nottingham)
Several fibre tracts can be accurately located using conventional Magnetic Resonance Images (MRI) of the human brain, including the corticospinal tract (CST), which appears as a T 1-weighted hypointense/T 2-weighted hyperintense patch in the posterior part of the posterior-limb of the internal capsule (PLIC). Here we use high-field MRI (7T) to assess the quantitative MRI properties of the CST at the PLIC level in 22 healthy young male participants. We used three different imaging modalities: the...
Published on Feb 1, 2011in Journal of Psychiatric Research3.92
Giuseppina Rametti11
Estimated H-index: 11
,
Beatriz Carrillo9
Estimated H-index: 9
(University of Barcelona)
+ 4 AuthorsAntonio Guillamón33
Estimated H-index: 33
(UNED: National University of Distance Education)
Background: Some gray and white matter regions of the brain are sexually dimorphic. The best MRI technique for identifying subtle differences in white matter is diffusion tensor imaging (DTI). The purpose of this paper is to investigate whether white matter patterns in female to male (FtM) transsexuals before commencing cross-sex hormone treatment are more similar to that of their biological sex or to that of their gender identity. Method: DTI was performed in 18 FtM transsexuals and 24 male and...
Cited By13
Newest
Published on Jul 7, 2019in Human Brain Mapping4.55
Bryce Geeraert3
Estimated H-index: 3
(U of C: University of Calgary),
Robert Marc Lebel (U of C: University of Calgary), Catherine Lebel23
Estimated H-index: 23
(U of C: University of Calgary)
Published on Mar 1, 2019in Journal of Research on Adolescence2.07
Anne-Lise Goddings9
Estimated H-index: 9
(UCL: University College London),
Anne Lise Goddings (UCL: University College London)+ 2 AuthorsBarbara R. Braams12
Estimated H-index: 12
(Harvard University)
Over the past two decades, there has been a tremendous increase in our understanding of structural and functional brain development in adolescence. However, understanding the role of puberty in this process has received much less attention. This review examines this relationship by summarizing recent research studies where the role of puberty was investigated in relation to brain structure, connectivity, and task-related functional magnetic resonance imaging (fMRI). The studies together suggest ...
Published on Nov 1, 2018in NeuroImage5.81
Rajpreet Chahal2
Estimated H-index: 2
(UC Davis: University of California, Davis),
Veronika Vilgis5
Estimated H-index: 5
(UC Davis: University of California, Davis)
+ 4 AuthorsAmanda E. Guyer32
Estimated H-index: 32
(UC Davis: University of California, Davis)
Author(s): Chahal, R; Vilgis, V; Grimm, KJ; Hipwell, AE; Forbes, EE; Keenan, K; Guyer, AE | Abstract: © 2018 Elsevier Inc. Patterns of pubertal maturation have been linked to vulnerability for emotion dysregulation disorders in girls, as well as white matter (WM) development, suggestive of a potential mechanism between pubertal maturation and emotional health. Because pubertal processes begin at varying ages (i.e., status, timing) and proceed at varying rates (i.e., tempo), identifying individua...
Published on Sep 1, 2018in Neuroscience & Biobehavioral Reviews8.00
Nandita Vijayakumar15
Estimated H-index: 15
(UO: University of Oregon),
Zdena Op de Macks1
Estimated H-index: 1
(UO: University of Oregon)
+ 1 AuthorsJennifer H. Pfeifer25
Estimated H-index: 25
(UO: University of Oregon)
Abstract Alongside the exponential flourish of research on age-related trajectories of human brain development during childhood and adolescence in the past two decades, there has been an increase in the body of work examining the association between pubertal development and brain maturation. This review systematically examines empirical research on puberty-related structural and functional brain development in humans, with the aim of identifying convergent patterns of associations. We emphasize ...
Published on 2018in bioRxiv
Sila Genc8
Estimated H-index: 8
,
Robert E. Smith26
Estimated H-index: 26
(Florey Institute of Neuroscience and Mental Health)
+ 6 AuthorsTimothy J. Silk17
Estimated H-index: 17
(Deakin University)
Purpose: White matter fibre development in childhood involves dynamic changes to microstructural organisation driven by increasing axon diameter, density, and myelination. However, there is a lack of longitudinal studies that have quantified advanced diffusion metrics to identify regions of accelerated fibre maturation, particularly across the early pubertal period. We applied a novel longitudinal fixel-based analysis (FBA) framework, in order to estimate microscopic and macroscopic white matter...
Published on Jan 1, 2018in NeuroImage5.81
Catherine Lebel23
Estimated H-index: 23
(U of C: University of Calgary),
Sean Deoni3
Estimated H-index: 3
(Memorial Hospital of Rhode Island)
Abstract Throughout infancy, childhood, and adolescence, our brains undergo remarkable changes. Processes including myelination and synaptogenesis occur rapidly across the first 2–3 years of life, and ongoing brain remodeling continues into young adulthood. Studies have sought to characterize the patterns of structural brain development, and early studies predominately relied upon gross anatomical measures of brain structure, morphology, and organization. MRI offers the ability to characterize a...
Published on Nov 14, 2017in Frontiers in Human Neuroscience2.87
Maiko Abel Schneider3
Estimated H-index: 3
(UFRGS: Universidade Federal do Rio Grande do Sul),
Poli Mara Spritzer29
Estimated H-index: 29
(UFRGS: Universidade Federal do Rio Grande do Sul)
+ 9 AuthorsMauricio Anés7
Estimated H-index: 7
Introduction: Gender dysphoria (GD) (DMS-5) is a condition marked by increasing psychological suffering that accompanies the incongruence between one's experienced or expressed gender and one's assigned gender. Manifestation of GD can be seen early on during childhood and adolescence. During this period, the development of undesirable sexual characteristics marks an acute suffering of being opposite to the sex of birth. Pubertal suppression with gonadotropin releasing hormone analogs (GnRHa) has...
Published on Oct 1, 2017in NeuroImage5.81
Sarah K. G. Jensen7
Estimated H-index: 7
(Harvard University),
Melissa M. Pangelinan8
Estimated H-index: 8
(UM: University of Michigan)
+ 6 AuthorsTomáš Paus82
Estimated H-index: 82
(MIND Institute)
Objective Previous studies have shown that both pre- and post-natal adversities, the latter including exposures to stress during childhood and adolescence, explain variation in structural properties of white matter (WM) in the brain. While previous studies have examined effects of independent stress exposures within one developmental period, such as childhood, we examine effects of stress across development using data from a prospective longitudinal study. More specifically, we ask how stressful...
Published on 2017in bioRxiv
Sila Genc8
Estimated H-index: 8
(University of Melbourne),
Charles B. Malpas8
Estimated H-index: 8
+ 2 AuthorsMarc L. Seal30
Estimated H-index: 30
Purpose: The corpus callosum is integral to the central nervous system, and continually develops with age by virtue of increasing axon diameter and ongoing myelination. Magnetic resonance imaging (MRI) techniques offer a means to disentangle these two aspects of white matter development. We investigate the profile of microstructural metrics across the corpus callosum, and assess the impact of age, sex and pubertal development on these processes. Methods: This study made use of two independent pa...
Published on Aug 17, 2017in PLOS ONE2.78
Alyssa Mah2
Estimated H-index: 2
(U of C: University of Calgary),
Bryce Geeraert3
Estimated H-index: 3
(U of C: University of Calgary),
Catherine Lebel23
Estimated H-index: 23
(U of C: University of Calgary)
Diffusion tensor imaging (DTI) studies have provided much evidence of white and subcortical gray matter changes during late childhood and early adolescence that suggest increasing myelination, axon density, and/or fiber coherence. Neurite orientation dispersion and density imaging (NODDI) can be used to further characterize development in white and subcortical grey matter regions in the brain by improving specificity of the MRI signal compared to conventional DTI. We used measures from NODDI and...
View next paperThe effects of puberty on white matter development in boys