Okazaki fragment maturation: nucleases take centre stage
Abstract
Completion of lagging strand DNA synthesis requires processing of up to 50 million Okazaki fragments per cell cycle in mammalian cells. Even in yeast, the Okazaki fragment maturation happens approximately a million times during a single round of DNA replication. Therefore, efficient processing of Okazaki fragments is vital for DNA replication and cell proliferation. During this process, primase-synthesized RNA/DNA primers are removed, and...
Paper Details
Title
Okazaki fragment maturation: nucleases take centre stage
Published Date
Jan 30, 2011
Volume
3
Issue
1
Pages
23 - 30
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