Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair
Abstract
Trinucleotide repeat (TNR) expansions and deletions are associated with human neurodegeneration and cancer. However, their underlying mechanisms remain to be elucidated. Recent studies have demonstrated that CAG repeat expansions can be initiated by oxidative DNA base damage and fulfilled by base excision repair (BER), suggesting active roles for oxidative DNA damage and BER in TNR instability. Here, we provide the first evidence that oxidative...
Paper Details
Title
Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair
Published Date
Feb 26, 2013
Journal
Volume
8
Issue
2
Pages
e56960 - e56960
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