Original paper
A High-Content Screening Assay for Small-Molecule Modulators of Oncogene-Induced Senescence
Abstract
Cellular senescence is a state of stable cell growth arrest. Activation of oncogenes such as RAS in mammalian cells typically triggers cellular senescence. Oncogene-induced senescence (OIS) is an important tumor suppression mechanism, and suppression of OIS contributes to cell transformation. Oncogenes trigger senescence through a multitude of incompletely understood downstream signaling events that frequently involve protein kinases. To...
Paper Details
Title
A High-Content Screening Assay for Small-Molecule Modulators of Oncogene-Induced Senescence
Published Date
Oct 1, 2013
Journal
Volume
18
Issue
9
Pages
1054 - 1061
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Notes
History