Insulin induced lipodystrophy

Insulin induced lipoatrophy and, more commonly, lipohypertrophy are dermatological complications of insulin therapy. Lipoatrophy is becoming less common with the advent of newer insulin analogues; however, lipohypertrophy is still prevalent. Whilst an immunological mechanism is postulated for lipoatrophy, direct local anabolic action of insulin is postulated for lipohypertrophy. Other factors which are implicated are the duration of diabetes,...