Pathogenesis of Human Metapneumovirus Lung Infection in BALB/c Mice and Cotton Rats
Abstract
Human metapneumovirus (hMPV) is a newly described member of the Paramyxoviridae family causing acute respiratory tract infections, especially in young children. We studied the pathogenesis of this viral infection in two experimental small animal models (BALB/c mice and cotton rats). Significant viral replication in the lungs of both animals was found following an intranasal challenge of 10(8) 50% tissue culture infectious doses (TCID50) and...
Paper Details
Title
Pathogenesis of Human Metapneumovirus Lung Infection in BALB/c Mice and Cotton Rats
Published Date
Jul 1, 2005
Journal
Volume
79
Issue
14
Pages
8894 - 8903
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