Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitus
Abstract
The function of endothelial progenitor cells (EPCs), which are key cells in vascular repair, is impaired in diabetes mellitus. Nitric oxide (NO) and reactive oxygen species can regulate EPC functions. EPCs tolerate oxidative stress by upregulating superoxide dismutase (SOD), the enzyme that neutralizes superoxide anion (O2-). Therefore, we investigated the roles of NO and SOD in glucose-stressed EPCs.The functions of circulating EPCs from...
Paper Details
Title
Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitus
Published Date
Jan 1, 2009
Journal
Volume
8
Issue
1
Pages
56 - 56
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