Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic

Volume: 86, Pages: 54 - 61
Published: Sep 1, 2015
Abstract
Studying the importance of genetic factors in a desired cell type or tissue necessitates the use of precise genetic tools. With the introduction of bacteriophage Cre recombinase/loxP mediated DNA editing and promoter-specific Cre expression, it is feasible to generate conditional knockout mice in which particular genes are disrupted in a cell type-specific manner in vivo. In cardiac myocytes, this is often achieved through α-myosin heavy chain...
Paper Details
Title
Prolonged Cre expression driven by the α-myosin heavy chain promoter can be cardiotoxic
Published Date
Sep 1, 2015
Volume
86
Pages
54 - 61
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