Sodium tungstate regulates food intake and body weight through activation of the hypothalamic leptin pathway

Sodium tungstate is an anti-obesity drug targeting peripheral tissues. In vivo, sodium tungstate reduces body weight gain and food intake through increasing energy expenditure and lipid oxidation, but it also modulates hypothalamic gene expression when orally administered, raising the possibility of a direct effect of sodium tungstate on the central nervous system.Sodium tungstate was administered intraperitoneally (ip) to Wistar rats, and its...