Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae
Abstract
Background The covalent linkage between DNA and the active site tyrosine of topoisomerase I can be stabilized by chemotherapeutic agents, adjacent DNA lesions, or mutational defects in the topoisomerase itself. Following collision with a replication fork, the covalent complex can be converted to a double-strand break. Tdp1, an enzyme that can hydrolyse the bond between topoisomerase I and DNA, is thought to be involved in the repair of these...
Paper Details
Title
Pathways for repair of topoisomerase I covalent complexes in Saccharomyces cerevisiae
Published Date
Aug 1, 2001
Journal
Volume
6
Issue
8
Pages
677 - 687
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