Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.

Volume: 28, Issue: 1, Pages: 64 - 74
Published: Jan 1, 2000
Abstract
Telomere shortening triggers replicative senescence in human fibroblasts. The inability of DNA polymerases to replicate a linear DNA molecule completely (the end replication problem) is one cause of telomere shortening. Other possible causes are the formation of single-stranded overhangs at the end of telomeres and the preferential vulnerability of telomeres to oxidative stress. To elucidate the relative importance of these possibilities, amount...
Paper Details
Title
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts.
Published Date
Jan 1, 2000
Volume
28
Issue
1
Pages
64 - 74
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