Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
Abstract
Most autoimmune diseases (AID) are linked to an imbalance between autoreactive effector T cells (Teffs) and regulatory T cells (Tregs). While blocking Teffs with immunosuppression has long been the only therapeutic option, activating/expanding Tregs may achieve the same objective without the toxicity of immunosuppression. We showed that low-dose interleukin-2 (ld-IL-2) safely expands/activates Tregs in patients with AID, such HCV-induced...
Paper Details
Title
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients
Published Date
Apr 1, 2015
Journal
Volume
58
Pages
48 - 58
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