Functional overlaps between XLF and the ATM-dependent DNA double strand break response
Abstract
Developing B and T lymphocytes generate programmed DNA double strand breaks (DSBs) during the V(D)J recombination process that assembles exons that encode the antigen-binding variable regions of antibodies. In addition, mature B lymphocytes generate programmed DSBs during the immunoglobulin heavy chain (IgH) class switch recombination (CSR) process that allows expression of different antibody heavy chain constant regions that provide different...
Paper Details
Title
Functional overlaps between XLF and the ATM-dependent DNA double strand break response
Published Date
Apr 1, 2014
Journal
Volume
16
Pages
11 - 22
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