Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Abstract
Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) population of ATMs in adipose tissue of obese mice that was not seen in lean mice. ATMs from lean mice expressed many genes...
Paper Details
Title
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Published Date
Jan 2, 2007
Volume
117
Issue
1
Pages
175 - 184
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