5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes
Abstract
Cytosine methylation is a frequent epigenetic modification restricting the activity of gene regulatory elements. Whereas DNA methylation patterns are generally inherited during replication, both embryonic and somatic differentiation processes require the removal of cytosine methylation at specific gene loci to activate lineage-restricted elements. However, the exact mechanisms facilitating the erasure of DNA methylation remain unclear in many...
Paper Details
Title
5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes
Published Date
Jan 1, 2013
Volume
14
Issue
5
Pages
R46 - R46
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