Homocysteine and the Brain in Midadult Life

High serum homocysteine (HCY) levels have been associated with thromboembolic cerebrovascular disease, but their relationship to microvascular disease is uncertain. Homocysteine also has a direct neurotoxic effect and has been linked to brain atrophy and an increased risk of Alzheimer disease.To examine the relationship of HCY levels to brain and cognitive measures in a healthy community sample.Cross-sectional study.Individuals residing in...