Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Abstract
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during mitosis. Short telomeres induce cellular senescence. As an indicator of oxidative stress and senescence (2 processes thought to be fundamental to aging), telomere length is hypothesized to be a biomarker of aging. This hypothesis has been tested for more than a decade with...
Paper Details
Title
Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither?
Published Date
Jan 1, 2013
Journal
Volume
35
Issue
1
Pages
112 - 131
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