Thin layer chromatography-autography-high resolution mass spectrometry analysis: accelerating the identification of acetylcholinesterase inhibitors

Volume: 26, Issue: 6, Pages: 404 - 412
Published: Jun 23, 2015
Abstract
The prevailing treatment for Alzheimer's disease is the use of acetylcholinesterase (AChE) inhibitors. Natural extracts are the principal source of AChE's inhibitors. However, their chemical complexity demands for simple, selective and rapid assays.To develop a strategy for identification of AChE inhibitors present in mixtures employing high resolution mass spectrometry (HRMS) and thin layer chromatography (TLC)-biological staining.The strategy...
Paper Details
Title
Thin layer chromatography-autography-high resolution mass spectrometry analysis: accelerating the identification of acetylcholinesterase inhibitors
Published Date
Jun 23, 2015
Volume
26
Issue
6
Pages
404 - 412
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