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Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults

Published on Dec 1, 2011in The American Journal of Clinical Nutrition 6.57
· DOI :10.3945/ajcn.111.020107
Phooi Tee Voon1
Estimated H-index: 1
(Malaysian Palm Oil Board),
Tony Kock Wai Ng1
Estimated H-index: 1
(Malaysian Palm Oil Board)
+ 1 AuthorsKalanithi Nesaretnam23
Estimated H-index: 23
(Malaysian Palm Oil Board)
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Abstract
Background: Dietary fat type is known to modulate the plasma lipid profile, but its effects on plasma homocysteine and inflammatory markers are unclear. Objective: We investigated the effects of high-protein Malaysian diets prepared with palm olein, coconut oil (CO), or virgin olive oil on plasma homocysteine and selected markers of inflammation and cardiovascular disease (CVD) in healthy adults. Design: A randomized-crossover intervention with 3 dietary sequences of 5 wk each was conducted in 45 healthy subjects. The 3 test fats, namely palmitic acid (16:0)‐rich palm olein (PO), lauric and myristic acids (12:0 + 14:0)‐rich CO, and oleic acid (18:1)‐rich virgin olive oil (OO), were incorporated at two-thirds of 30% fat calories into high-protein Malaysian diets. Results: No significant differences were observed in the effects of the 3 diets on plasma total homocysteine (tHcy) and the inflammatory markers TNF-a, IL-1b, -6, and -8, high-sensitivity C-reactive protein, and interferon-c. Diets prepared with PO and OO had comparable nonhypercholesterolemic effects; the postprandial total cholesterol for both diets and all fasting lipid indexes for the OO diet were significantly lower (P , 0.05) than for the CO diet. Unlike the PO and OO diets, the CO diet was shown to decrease postprandial lipoprotein(a). Conclusion: Diets that were rich in saturated fatty acids prepared with either PO or CO, and an OO diet that was high in oleic acid, did not alter postprandial or fasting plasma concentrations of tHcy and selected inflammatory markers. This trial was registered at clinicaltrials.gov as NCT00941837. Am J Clin Nutr doi: 10. 3945/ajcn.111.020107.
  • References (38)
  • Citations (59)
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References38
Newest
Published on Apr 1, 2011in Lipids 2.14
Kim-Tiu Teng3
Estimated H-index: 3
(UM: University of Malaya),
Gowri Nagapan1
Estimated H-index: 1
(Malaysian Palm Oil Board)
+ 1 AuthorsKalanithi Nesaretnam23
Estimated H-index: 23
(Malaysian Palm Oil Board)
Postprandial lipemia impairs insulin sensitivity and triggers the pro-inflammatory state which may lead to the progression of cardiovascular diseases. A randomized, crossover single-blind study (n = 10 healthy men) was designed to compare the effects of a high-fat load (50 g fat), rich in palmitic acid from both plant (palm olein) or animal source (lard) versus an oleic acid-rich fat (virgin olive oil) on lipemia, plasma glucose, insulin and adipocytokines. Serum triacylglycerol (TAG) concentrat...
Published on Apr 1, 2011in Lipids 2.14
Tine Tholstrup26
Estimated H-index: 26
(UCPH: University of Copenhagen),
Kim-Tiu Teng3
Estimated H-index: 3
(UM: University of Malaya),
Marianne Raff8
Estimated H-index: 8
(UCPH: University of Copenhagen)
Contrary to other long chain saturated fatty acids (SFA), fats high in stearic acid do not raise plasma cholesterol concentrations, however, a slight elevation in inflammatory markers, plasma fibrinogen and interleukin-6 (IL-6), has been observed in the fasting state. The effect of stearic acid on inflammation in the postprandial state has not yet been reported. We conducted a single blind crossover, randomized, postprandial study to compare the effects of a fat load of cocoa butter high in stea...
Published on Feb 1, 2011in Journal of Inherited Metabolic Disease 4.29
Robert Clarke109
Estimated H-index: 109
(University of Oxford),
Jim Halsey8
Estimated H-index: 8
(University of Oxford)
+ 1 AuthorsSarah Lewington41
Estimated H-index: 41
(University of Oxford)
Moderately elevated homocysteine levels have been associated with a higher risk of cardiovascular disease in observational studies, but whether these associations are causal is uncertain. Randomized trials of dietary supplementation with B vitamins were set up to assess whether lowering homocysteine levels could reduce the risk of vascular disease. This review is based on a meta-analysis of published results of eight homocysteine-lowering trials for preventing vascular disease. The eight trials ...
Published on May 1, 2010in Lipids 2.14
Kim-Tiu Teng3
Estimated H-index: 3
(UM: University of Malaya),
Phooi-Tee Voon1
Estimated H-index: 1
(Malaysian Palm Oil Board)
+ 1 AuthorsKalanithi Nesaretnam23
Estimated H-index: 23
(Malaysian Palm Oil Board)
Knowledge about the effects of dietary fats on subclinical inflammation and cardiovascular disease risk are mainly derived from studies conducted in Western populations. Little information is available on South East Asian countries. This current study investigated the chronic effects on serum inflammatory markers, lipids, and lipoproteins of three vegetable oils. Healthy, normolipidemic subjects (n = 41; 33 females, 8 males) completed a randomized, single-blind, crossover study. The subjects con...
Published on Jun 1, 2009in Atherosclerosis 4.25
Y. Jimenez-Gomez20
Estimated H-index: 20
(UCO: University of Córdoba (Spain)),
Jose Lopez-Miranda51
Estimated H-index: 51
(UCO: University of Córdoba (Spain))
+ 7 AuthorsFrancisco Perez-Jimenez47
Estimated H-index: 47
(UCO: University of Córdoba (Spain))
Abstract Background Inflammation is crucial in all stages of atherosclerosis, and few studies have investigated the effect of dietary fat on markers of inflammation related to this disease during the postprandial period. Objective To evaluate the chronic effects of dietary fat on the postprandial expression of proinflammatory genes in peripheral blood mononuclear cells (PBMCs) in healthy subjects. Design 20 healthy men followed three different diets for 4 weeks each, according to a randomized cr...
Published on Jan 1, 2009in Journal of Nutrition 4.42
Arion Kennedy13
Estimated H-index: 13
(UNCG: University of North Carolina at Greensboro),
Kristina Martinez17
Estimated H-index: 17
(UNCG: University of North Carolina at Greensboro)
+ 2 AuthorsMichael McIntosh29
Estimated H-index: 29
This review highlights the inflammatory and insulin-antagonizing effects of saturated fatty acids (SFA), which contribute to the development of metabolic syndrome. Mechanisms responsible for these unhealthy effects of SFA include: 1) accumulation of diacylglycerol and ceramide; 2) activation of nuclear factor-kB, protein kinase C-u, and mitogen-activated protein kinases, and subsequent induction of inflammatory genes in white adipose tissue, immune cells, and myotubes; 3) decreased PPARg coactiv...
Published on Jan 1, 2009in Annals of Nutrition and Metabolism 3.05
Claudio Galli47
Estimated H-index: 47
(University of Milan),
Philip C. Calder101
Estimated H-index: 101
(University of Southampton)
intakes, and the relative relevance of direct AA intakes versus endogenous production, have not been fully assessed. • Formation of LC n–3 FA, especially to DHA, from ALA appears to be rather inefficient, although somewhat higher conversion rates have been shown in premenopausal women than in men [Giltay et al., 2004]. • There is competition between the two metabolic pathways, especially at the desaturation steps, and at the cellular level competition may also take place for the esterification i...
Published on Nov 1, 2008in Mayo Clinic Proceedings 7.09
Linda Humphrey31
Estimated H-index: 31
,
Rongwei Fu33
Estimated H-index: 33
(OHSU: Oregon Health & Science University)
+ 2 AuthorsMark Helfand55
Estimated H-index: 55
OBJECTIVE To determine whether an elevated homocysteine level is an independent risk factor for the development of coronary heart disease (CHD) to aid the US Preventive Services Task Force in its evaluation of novel risk factors for incident CHD. METHODS Studies of homocysteine and CHD were identified by searching MEDLINE (1966 through March 2006). We obtained additional articles by reviewing reference lists from prior reviews, original studies, editorials, and Web sites and by consulting expert...
Published on Jun 1, 2007in The American Journal of Clinical Nutrition 6.57
Paula Berstad9
Estimated H-index: 9
(University of Oslo),
Svetlana V. Konstantinova6
Estimated H-index: 6
(University of Bergen)
+ 6 AuthorsSamera Azeem Qureshi60
Estimated H-index: 60
Background: The intake of n3 (formerly called omega-3) fatty acids (FAs) may be inversely associated with plasma total homocysteine (tHcy) concentrations, but the epidemiologic data are sparse. Objective: We examined the association between dietary fat and tHcy in a Norwegian population. Design: A cross-sectional, population-based study of 5917 subjects in2agegroups(47–49and71–74yold)wasconductedwiththeuse of food-frequency questionnaires and measurement of plasma tHcy concentrations. Results: T...
Published on Jun 1, 2007in Biochemical and Biophysical Research Communications 2.71
Phyllis S. Laine2
Estimated H-index: 2
,
Eric A. Schwartz12
Estimated H-index: 12
+ 4 AuthorsPeter D. Reaven49
Estimated H-index: 49
Abstract It is now recognized that cross-talk between adipocytes and adipose tissue stromal cells such as macrophages contributes to local and systemic inflammation. One factor from adipocytes that may participate in this interaction and that is frequently elevated in inflammatory conditions such as obesity, insulin resistance, and type 2 diabetes is free fatty acids (FFA). To investigate the potential for FFA to enhance macrophage inflammation, we exposed U937 macrophages to physiological level...
Cited By59
Newest
Published on May 16, 2019in Advances in Nutrition 7.24
Phooi Tee Voon1
Estimated H-index: 1
(Malaysian Palm Oil Board),
Sin Tien Lee (UPM: Universiti Putra Malaysia)+ 4 AuthorsAugustine Soon Hock Ong6
Estimated H-index: 6
Published on Jun 21, 2019in European Journal of Clinical Nutrition 3.11
Welma Stonehouse16
Estimated H-index: 16
,
Bianca Benassi-Evans + 1 AuthorsMahinda Y. Abeywardena33
Estimated H-index: 33
Hypercholesterolaemic effects of saturated fatty acids (SFA) may be influenced not only by the chain length, but also by their specific location within the triacylglycerol (TAG) molecule. We examined the hypothesis that dietary fats rich in SFA, but containing mostly unsaturated fatty acids in the sn-2 position with most SFA in sn-1 and -3 (palm olein [PO] and cocoa butter [CB]) will have similar serum lipid outcomes to unsaturated olive oil (OO). Thirty-eight participants (20–40 yr, 18.5– ≤ 27....
Published on May 1, 2019in Food and Chemical Toxicology 3.77
Ruijie Liu10
Estimated H-index: 10
(University of Texas at Austin),
Min Cheng (Jiangnan University)+ 6 AuthorsJ. Thomas Brenna36
Estimated H-index: 36
(University of Texas at Austin)
Abstract Despite its 50-year history, the conventional diet-heart hypothesis holding that dietary saturated fats raise serum cholesterol, and with it, cardiovascular risk, remains controversial. Harsh chemical and physical treatment generates process contaminants, and refined oils raise serum and tissue cholesterol in vivo independent of saturated fat content. We developed an in vitro bioassay for rapidly assessing the influence of oils on cholesterol metabolism in the human liver HepG2 cell lin...
Chen Cheng (SEU: Southeast University), Di Wang (SEU: Southeast University)+ 11 AuthorsGuofang Shu3
Estimated H-index: 3
(SEU: Southeast University)
AbstractThe aim of this study is to investigate the effects of palm olein (POL), cocoa butter (CB) and extra virgin olive oil (EVOO) on the lipid profile and low-density lipoprotein subfractions in a young, healthy Chinese population. After screening, 72 subjects were randomly assigned to three groups, and an 18-week randomized crossover trial was conducted. The first phase was a 2-week run-in period, followed by three phases of the 4-week experimental periods with a 2-week washout period betwee...
Published on Feb 17, 2019in Journal of The American College of Nutrition 2.08
Taylor C. Wallace12
Estimated H-index: 12
(GMU: George Mason University)
AbstractCoconut oil is a mainstream edible oil that is extracted from the kernel of mature coconuts harvested from the coconut palm. The two main types of coconut oil—copra oil and virgin coconut o...
Published on Jan 1, 2019
Álvaro Hernáez8
Estimated H-index: 8
,
Julieta Valussi + 2 AuthorsMontserrat Fitó
Published on Oct 1, 2018in The American Journal of Clinical Nutrition 6.57
Nisha Panth6
Estimated H-index: 6
(University of Newcastle),
Kylie A. Abbott4
Estimated H-index: 4
(University of Newcastle)
+ 2 AuthorsManohar L. Garg47
Estimated H-index: 47
(University of Newcastle)
Published on Sep 1, 2018in Journal of Lipid Research 4.74
Lukas Schwingshackl30
Estimated H-index: 30
,
Berit Bogensberger2
Estimated H-index: 2
(University of Vienna)
+ 3 AuthorsGeorg F. Hoffmann63
Estimated H-index: 63
(University of Vienna)