Original paper
Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
Abstract
Human metapneumovirus (hMPV) infection can cause acute lower respiratory tract illness in infants, the immunocompromised, and the elderly. Currently there are no licensed preventative measures for hMPV infections. Using a variant of hMPV/NL/1/00 that does not require trypsin supplementation for growth in tissue culture, we deleted the M2-2 gene and evaluated the replication of rhMPV/DeltaM2-2 virus in vitro and in vivo.In vitro studies showed...
Paper Details
Title
Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters
Published Date
Jan 1, 2008
Journal
Volume
5
Issue
1
Pages
69 - 69
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Notes
History