Trophic enteral nutrition increases hepatic glutathione and protects against peroxidative damage after exposure to endotoxin

During total parenteral nutrition (TPN), hepatic concentration of the important intracellular antioxidant glutathione (GSH) is decreased. This study sought to determine whether enteral trophic (small quantity) feeding of GSH precursors would increase hepatic GSH levels during TPN and result in decreased peroxidative injury after endotoxin exposure.Sprague-Dawley rats received full TPN for 7 days with postpyloric infusions of either (1) amino...