Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
Abstract
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration-response curves suggest more complex biological effects, such as multiple-binding sites or multiple targets. Here, we investigate a physical property-based mechanism for bell-shaped curves. Beginning with the observation that some drugs form colloidal aggregates at...
Paper Details
Title
Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves
Published Date
Jan 15, 2014
Journal
Volume
9
Issue
3
Pages
777 - 784
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