Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Abstract
In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation. We have established a spontaneously transformed human epithelial cell line from adult skin, which maintains full epidermal differentiation capacity. This HaCaT cell line is obviously immortal (greater than 140 passages), has a...
Paper Details
Title
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Published Date
Mar 1, 1988
Journal
Volume
106
Issue
3
Pages
761 - 771
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Notes
History