Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival
Abstract
Signals from the BCR are required for Ag-specific B cell recruitment into the immune response. Binding of Ag to the BCR induces phosphorylation of immune receptor tyrosine-based activation motifs in the cytoplasmic domains of the CD79a and CD79b signaling subunits, which subsequently bind and activate the Syk protein tyrosine kinase. Earlier work with the DT40 chicken B cell leukemia cell line showed that Syk was required to transduce BCR...
Paper Details
Title
Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival
Published Date
May 15, 2015
Journal
Volume
194
Issue
10
Pages
4650 - 4656
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