Chimeric Receptors Indicate That Phenylalanine 39 Is a Major Contributor to Insulin Specificity of the Insulin Receptor

Volume: 269, Issue: 52, Pages: 32942 - 32946
Published: Dec 30, 1994
Abstract
The exact nature of how the insulin molecule interacts with the insulin receptor is obscure although chimeric receptors have shown that the ligand specificity of the insulin receptor and the IGF-I receptor (i.e. the sequences that discriminate between insulin and insulin-like growth factor I) reside in different regions of a common binding site and that the N-terminal 68 amino acids of the insulin receptor are involved in conferring specificity...
Paper Details
Title
Chimeric Receptors Indicate That Phenylalanine 39 Is a Major Contributor to Insulin Specificity of the Insulin Receptor
Published Date
Dec 30, 1994
Volume
269
Issue
52
Pages
32942 - 32946
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