The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
Abstract
The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their main substrates are the ectodomains of other transmembrane proteins. These substrates include precursor forms of growth factors, cytokines, growth factor receptors, cytokine receptors and several different types of adhesion molecules....
Paper Details
Title
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
Published Date
Jun 9, 2011
Journal
Volume
8
Issue
1
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