Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma
Abstract
Oncolytic herpes simplex viruses (HSVs) represent a novel frontier against tumors resistant to standard therapies, like glioblastoma (GBM). The oncolytic HSVs that entered clinical trials so far showed encouraging results; however, they are marred by the fact that they are highly attenuated. We engineered HSVs that maintain unimpaired lytic efficacy and specifically target cells that express tumor-specific receptors, thus limiting the...
Paper Details
Title
Replication-competent Herpes Simplex Virus Retargeted to HER2 as Therapy for High-grade Glioma
Published Date
May 1, 2012
Journal
Volume
20
Issue
5
Pages
994 - 1001
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Notes
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