Original paper
Structural biology of the alternative pathway convertase
Abstract
Complement convertases are bimolecular complexes expressing protease activity only against C3 and C5. Their action is necessary for production of the biological activities of the complement system. Formation of these complexes proceeds through sequential protein-protein interactions and proteolytic cleavages of high specificity. Recent structural, mutational and functional data on factors D and B have significantly enhanced our understanding of...
Paper Details
Title
Structural biology of the alternative pathway convertase
Published Date
Apr 1, 2001
Journal
Volume
180
Issue
1
Pages
123 - 135
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Notes
History