DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes

Volume: 42, Issue: 7, Pages: 433 - 439
Published: Jul 1, 2010
Abstract
Chromosomal DNA replication in eukaryotic cells is highly complicated and sophisticatedly regulated. Owing to its large size, a typical eukaryotic genome contains hundreds to tens of thousands of initiation sites called DNA replication origins where DNA synthesis takes place. Multiple initiation sites remove the constraint of a genome size because only a certain amount of DNA can be replicated from a single origin in a limited time. The...
Paper Details
Title
DNA replication origins, ORC/DNA interaction, and assembly of pre-replication complex in eukaryotes
Published Date
Jul 1, 2010
Volume
42
Issue
7
Pages
433 - 439
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