A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation

Volume: 7, Issue: 6, Pages: 1321 - 1327
Published: Jun 1, 2001
Abstract
null The inhibition of GSK3 is required for the stimulation of glycogen and protein synthesis by insulin and the specification of cell fate during development. Here, we demonstrate that the insulin-induced inhibition of GSK3 and its unique substrate specificity are explained by the existence of a phosphate binding site in which Arg-96 is critical. Thus, mutation of Arg-96 abolishes the phosphorylation of null glycogen synthase as well as...
Paper Details
Title
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
Published Date
Jun 1, 2001
Volume
7
Issue
6
Pages
1321 - 1327
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