Molecular scanning of the human PPARα gene: association of the L162V mutation with hyperapobetalipoproteinemia

Peroxisome proliferator-activated receptor alpha (PPARα) is a member of the steroid hormone receptor super family involved in the control of cellular lipid utilization. This makes PPARα a candidate gene for type 2 diabetes and dyslipidemia. The aim of this study was to investigate whether genetic variation in the human PPARα gene can influence the risk of type 2 diabetes and dyslipidemia among French Canadians. We therefore first determined the...