ENDURANCE TRAINING ACTIVATES PANCREATIC ISLETS AMP-ACTIVATED KINASE-UNCOUPLING PROTEIN 2 PATHWAY AND REDUCES INSULIN SECRETION

Endurance exercise is known to enhance peripheral insulin sensitivity and reduce insulin secretion. However, it is unknown whether the latter effect is due to the reduction in plasma substrate availability or alterations in β-cell secretory machinery. Here, we tested the hypothesis that endurance exercise reduces insulin secretion by altering the intracellular energy-sensitive AMP-activated kinase (AMPK) signaling pathway. Male Wistar rats were...