Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Volume: 4, Issue: 3, Pages: 151 - 163
Published: Mar 1, 2015
Abstract
Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. We utilize flux balance computational modeling to develop the first systems-level analysis of IR metabolism in fasted and fed states, and varying nutrient conditions. We systematically perturb...
Paper Details
Title
Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes
Published Date
Mar 1, 2015
Volume
4
Issue
3
Pages
151 - 163
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