Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes
Abstract
Dysregulated muscle metabolism is a cardinal feature of human insulin resistance (IR) and associated diseases, including type 2 diabetes (T2D). However, specific reactions contributing to abnormal energetics and metabolic inflexibility in IR are unknown. We utilize flux balance computational modeling to develop the first systems-level analysis of IR metabolism in fasted and fed states, and varying nutrient conditions. We systematically perturb...
Paper Details
Title
Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes
Published Date
Mar 1, 2015
Journal
Volume
4
Issue
3
Pages
151 - 163
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History