Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
Abstract
Activation of the complement system generates potent chemoattractants and leads to the opsonization of cells for immune clearance. Short-lived protease complexes cleave complement component C3 into anaphylatoxin C3a and opsonin C3b. Here we report the crystal structure of the C3 convertase formed by C3b and the protease fragment Bb, which was stabilized by the bacterial immune-evasion protein SCIN. The data suggest that the proteolytic...
Paper Details
Title
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
Published Date
Jun 7, 2009
Journal
Volume
10
Issue
7
Pages
721 - 727
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History