The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele
Abstract
p53 loss of heterozygosity (p53LOH) is frequently observed in Li-Fraumeni syndrome (LFS) patients who carry a mutant (Mut) p53 germ-line mutation. Here, we focused on elucidating the link between p53LOH and tumor development in stem cells (SCs). Although adult mesenchymal stem cells (MSCs) robustly underwent p53LOH, p53LOH in induced embryonic pluripotent stem cells (iPSCs) was significantly attenuated. Only SCs that underwent p53LOH induced...
Paper Details
Title
The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele
Published Date
May 16, 2014
Journal
Volume
21
Issue
9
Pages
1419 - 1431
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