Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein.

Volume: 170, Issue: 6, Pages: 2467 - 2470
Published: Dec 1, 2003
Abstract
Purpose: The metal binding protein metallothionein (MT) confers drug resistance when MT is induced in tumor tissues. Cisplatin is known to induce MT synthesis in tumor tissues, which may lead to drug resistance. We examined whether a difference in the administration schedule of cisplatin affect the efficiency of MT induction.Materials and Methods: Balb/c nude mice were inoculated with NMB-1 human bladder tumor tissues and injected with cisplatin...
Paper Details
Title
Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein.
Published Date
Dec 1, 2003
Volume
170
Issue
6
Pages
2467 - 2470
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