PKCη directs induction of IRF-4 expression and Ig κ gene rearrangement in pre-BCR signaling pathway

Volume: 20, Issue: 11, Pages: 1417 - 1426
Published: Sep 9, 2008
Abstract
Pre-B cell receptor (pre-BCR) signals promote pre-B cell differentiation, in which the adaptor protein B-cell linker (BLNK) plays a crucial role. However, the molecular pathways downstream of BLNK are currently unclear. Utilizing pre-B leukemia cell lines (BKO84 and others) derived from BLNK-deficient mice as in vitro models of the pre-B cell differentiation, we have demonstrated that reconstitution of BLNK as well as an active form of protein...
Paper Details
Title
PKCη directs induction of IRF-4 expression and Ig κ gene rearrangement in pre-BCR signaling pathway
Published Date
Sep 9, 2008
Volume
20
Issue
11
Pages
1417 - 1426
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